Journal of Medical Physics and Applied Sciences

Evaluation of Mast Cell Stabilization Potential of Euphorbia Wallichaii Hook

The present research article find out the potential of Euphorbia wallichaii root extract on stabilization of mast cells or antihistaminic activities in albino rats. The aqueous root extract of the Euphorbia wallichaii when screened for the presence of different phytochemical, revealed the presence of steroids, triterpenoides and flavonoides. The rats were divided into four groups. The group I which was control sensitized showed 88.20 ± 2% disrupted mast cells and 15.50 ± 2% of intact mast cells, the group II was orally treated with aqueous root extract at the dose of 50 mg/kg b.w showed the disruption of mast cells 29.80 ± 2% and intact mast cells were 71.20 ± 2% but at the dose of 100 mg/kg b.w weight in group III 24.70 ± 2% of mast cells were disrupted and 81.10 ± 2% of mast cells were intact. The group IV was treated with Prednisolone at 10 mg/kg b.w showed the 84.50 ± 2% of intact mast cells and 20.40 ± 2% of disrupted mast cells. This mast cell stabilization property of euphorbia wallichaii root seems to be due to the presence of high content of steroids, triterpenoides and flavonoides in the plant extract.

Author(s):

Firdous A. Mala, Abeer Hashem , Elsayed Fathi Abd Allah, and Mekhled M. Alenazi

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